(Xian 2019) 4-Factor Prothrombin Complex Concentrates (4F-PCC), or K-Centra, is a derivative of human plasma and is explicitly used to reverse vitamin K antagonists such as warfarin and non-specifically in the reversal of DOACs.Īndexanet alfa (AA) is a decoy protein specific to the emergent reversal of Factor Xa inhibitor-associated bleeding. BACKGROUND: Direct oral anticoagulants (DOACs) such as rivaroxaban and apixaban have become more prevalent in the aging population and are associated with intracranial bleeding at rates up to 4.2%.
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